Hyaluronic Acid (HA) is a powerhouse ingredient in modern skincare, revered for its unparalleled ability to attract and hold moisture—up to 1,000 times its weight in water. This makes it essential for plumping, hydrating, and smoothing the skin.
While all hyaluronic acid serums aim to boost hydration, their formulations differ dramatically, incorporating unique molecular weights of HA and a supporting cast of specialty ingredients. Here is a breakdown of five high-performance HA serums and what sets each one apart.

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1. Osea Hyaluronic Acid Sea Serum: The Marine Hydrator
The Osea Hyaluronic Acid Sea Serum distinguishes itself by leaning heavily into marine actives. This is a great choice for those who appreciate natural, ocean-derived ingredients.
- Unique Ingredients: The formula contains multiple forms of Hyaluronic Acid (Sodium Hyaluronate and Hydrolyzed Hyaluronic Acid) for multi-depth moisture, but the stars are the Seaweed Extracts and Snow Mushroom Extract (Tremella Fuciformis). Snow mushroom is a fantastic humectant that rivals HA in its water-holding capacity, helping to lock in moisture and promote a visibly dewy, plump look.
- Key Focus: Multi-molecular weight HA combined with potent sea botanicals.

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2. Dr. Barbara Sturm Hyaluronic Serum: The Luxury Minimalist
Dr. Barbara Sturm’s Hyaluronic Serum is known for its focused, medical-grade approach, offering intense, multi-layered hydration as a fundamental step in any routine.
- Key Focus: A proprietary high concentration of different molecular weights of HA for instant and long-term hydration.
- Unique Ingredients: The formula features low, medium, and high molecular weight Hyaluronic Acid molecules to ensure surface plumping and deeper hydration. Its primary anti-aging support comes from Purslane Extract (Portulaca Oleracea), an antioxidant-rich botanical often featured in the brand’s products to soothe the skin and reduce visible signs of irritation

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3. M-61 Hydraboost Serum 2.0: The Peptide Powerhouse
The M-61 Hydraboost Serum 2.0 goes beyond simple hydration, incorporating powerful firming and soothing agents to address signs of aging and overall skin texture.
- Key Focus: Hydration, firming, and wrinkle reduction.
- Unique Ingredients: This serum features a blend of multiple forms of HA alongside a collection of Peptides (such as Palmitoyl Tripeptide-1 and Acetyl Hexapeptide-8) that help promote firmness and visibly reduce fine lines. It also includes Vitamin B5 (Panthenol) to bind water to the skin, and Tamarind and Centella Asiatica (Cica) to hydrate and soothe.

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4. Kiehl’s Ultra Pure High Potency Serum 1.5% Hyaluronic Acid: The Focused Formula
For those who believe less is more, the Kiehl’s Ultra Pure High Potency Serum offers a concentrated dose of hydration in a remarkably simple formula.

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5. Dermalogica Circular Hydration Serum: The Complete Cycle Solution
The Dermalogica Circular Hydration Serum is formulated to address the full scope of dehydration, from initial quenching to prevention of future moisture loss.
- Key Focus: Achieving continuous, circular hydration by attracting, retaining, and sealing in moisture.
- Unique Ingredients: This formula is highly comprehensive, utilizing Polyglutamic Acid (a powerful ingredient derived from fermented soy that enhances the skin’s moisture reserves) and Lactic Acid for gentle resurfacing and hydration. It also includes an Algae Extract-infused moisturizing matrix and a Postbiotic Blend (featuring Lactobacillus Ferment and Oat Kernel Extract) to help balance the skin’s microbiome and strengthen the skin barrier for prolonged hydration.
| Serum Name | Key Hyaluronic Acid Forms | Notable Supporting Ingredients | Characteristics |
| Osea Hyaluronic Acid Sea Serum | Multiple molecular weights of Hyaluronic Acid, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid | Seaweed (like Codium Fragile, Gigartina Skottsbergii, Macrocystis Pyrifera, Undaria Pinnatifida), Snow Mushroom Extract (Tremella Fuciformis Sporocarp Extract), Betaine, Bacillus Ferment | Focus on multi-molecular weight HA and potent marine actives (seaweed) for plumping, hydration, and a dewy look. Also includes Snow Mushroom for moisture retention. |
| Dr. Barbara Sturm Hyaluronic Serum | High concentration of low, medium, and high molecular weighted Hyaluronic Molecules (Hyaluronic Acid, Sodium Hyaluronate) | Purslane Extract (Portulaca Oleracea Ferment Extract), Sea Water (in some versions), Lumicol (in “Darker Skin Tones” version) | Focus on intense, multi-depth hydration and anti-aging benefits. Contains Purslane for antioxidant and anti-irritation properties. |
| M-61 Hydraboost Serum 2.0 | Hyaluronic Acid, Sodium Hyaluronate | Multiple Peptides (Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, etc.), Vitamin B5 (Panthenol), Tamarind Seed Polysaccharide, Aloe, Centella Asiatica Extract | Focus on hydration, firming, and fine line reduction. Contains a blend of peptides for anti-aging and Vitamin B5 for binding water to the skin. |
| Kiehl’s Ultra Pure High Potency Serum 1.5% Hyaluronic Acid | 1.5% Hyaluronic Acid (Sodium Hyaluronate) | Glycerin | Simple, highly concentrated formula with only seven total ingredients (Aqua/Water, Glycerin, Sodium Hyaluronate, Phenoxyethanol, Chlorphenesin, Tetrasodium Glutamate Diacetate, Citric Acid) for intensive, targeted hydration. Free of colorants and fragrance. |
| Dermalogica Circular Hydration Serum | Hyaluronic Acid, Sodium Hyaluronate | Algae Extract, Polyglutamic Acid, Lactic Acid, Plant-Derived Sugars and Amino Acids, Postbiotic Blend (Lactobacillus Ferment, Oat Kernel Extract) | Designed for complete hydration cycle (flooding, replenishing, preventing loss). Uses multiple ingredients like Algae, Polyglutamic Acid, and Lactic Acid to enhance moisture retention and barrier function. |
Disclaimer: This article may contain affiliate links. Product images have been edited and combined by Glow-lyn for informational purposes. All original images are © their respective brands.

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